New approaches to the pharmacological management of generalized anxiety disorder.

摘要: Introduction: Selective serotonin reuptake inhibitors (SSRIs) and serotonine Inhibitors (SNRIs) together with pregabalin are actually considered by international guidelines as the first-line choice for generalized anxiety disorder (GAD) treatment. However, 50% of GAD patients have poor response to treatments different molecules, such atypical antipsychotics mood stabilizers, been used treating this condition. Purpose present article is provide an overview most recent pharmacological approaches treatment rationale their use. Areas covered: A research in main database sources has conducted obtain new (anticonvulsants, antipsychotics, agomelatine, memantine, ondansetron riluzole). Expert opinion: Among unlabelled quetiapine seems robust evidence efficacy GAD. Valproic acid agomelatine appear be effective G...