Lipid transfer inhibitor protein defines the participation of high density lipoprotein subfractions in lipid transfer reactions mediated by cholesterol ester transfer protein (CETP).

摘要: Cholesterol ester transfer protein (CETP) moves triglyceride (TG) and cholesteryl (CE) between lipoproteins. CETP has no apparent preference for high (HDL) or low (LDL) density lipoprotein as lipid donor to very (VLDL), the HDL observed in plasma is due suppression of LDL transfers by inhibitor (LTIP). Given heterogeneity HDL, a demonstrated ability subfractions bind LTIP, we examined whether LTIP might also control CETP-facilitated flux among subfractions. CETP-mediated CE from [3H]CE VLDL various lipoproteins, combined on an equal phospholipid basis, ranged 2-fold followed order: HDL3 > HDL2. inhibited HDL2 at one-half rate LDL. In contrast, was stimulated, resulting that 3-fold greater than Long-term mass experiments confirmed these findings further established previously stimulation activity solely its HDL3. TG enrichment HDL2, which occurs during cycle, ∼2-fold blocked almost completely. This suggests keeps constant regardless status. Overall, results show tailors remodeling particles subclass-specific ways, strongly implicating regulator metabolism.