De novo design of a fluorescence-activating β-barrel
作者： Jiayi Dou , Anastassia A. Vorobieva , William Sheffler , Lindsey A. Doyle , Hahnbeom Park
DOI: 10.1038/S41586-018-0509-0
关键词: Plasma protein binding 、 Protein domain 、 Amino acid 、 Barrel 、 Biophysics 、 Globular protein 、 Ligand 、 Chemistry 、 Protein structure 、 Protein folding
摘要: … Therefore, we chose to build β-barrel backbones starting from a 2D map … f–j, Superpositions of the crystal structure (grey) and the design model (pink): overall backbone superposition (f)…
rcsb.org
harvard.edu
nature.com参考文章(57)
F.R. Salemme, D.W. Weatherford, Conformational and geometrical properties of β-sheets in proteins: I. Parallel β-sheets☆ Journal of Molecular Biology. ,vol. 146, pp. 101- 117 ,(1981) , 10.1016/0022-2836(81)90368-5
Judith M. Lalonde, David A. Bernlohr, Leonard J. Banaszak, The up-and-down beta-barrel proteins. The FASEB Journal. ,vol. 8, pp. 1240- 1247 ,(1994) , 10.1096/FASEBJ.8.15.8001736
Zbyszek Otwinowski, Wladek Minor, Processing of X-ray diffraction data collected in oscillation mode Methods in Enzymology. ,vol. 276, pp. 307- 326 ,(1997) , 10.1016/S0076-6879(97)76066-X
F.R. Salemme, Conformational and geometrical properties of β-sheets in proteins: III. Isotropically stressed configurations Journal of Molecular Biology. ,vol. 146, pp. 143- 156 ,(1981) , 10.1016/0022-2836(81)90370-3
Hahnbeom Park, Frank DiMaio, David Baker, The Origin of Consistent Protein Structure Refinement from Structural Averaging Structure. ,vol. 23, pp. 1123- 1128 ,(2015) , 10.1016/J.STR.2015.03.022
Patrick Conway, Michael D. Tyka, Frank DiMaio, David E. Konerding, David Baker, Relaxation of backbone bond geometry improves protein energy landscape modeling Protein Science. ,vol. 23, pp. 47- 55 ,(2014) , 10.1002/PRO.2389
Kazuo Fujiwara, Shinichi Ebisawa, Yuka Watanabe, Hiromi Toda, Masamichi Ikeguchi, Local sequence of protein β‐strands influences twist and bend angles Proteins. ,vol. 82, pp. 1484- 1493 ,(2014) , 10.1002/PROT.24518
I. Lasters, S. J. Wodak, P. Alard, E. van Cutsem, Structural principles of parallel beta-barrels in proteins. Proceedings of the National Academy of Sciences of the United States of America. ,vol. 85, pp. 3338- 3342 ,(1988) , 10.1073/PNAS.85.10.3338
Brian Kuhlman, Gautam Dantas, Gregory C. Ireton, Gabriele Varani, Barry L. Stoddard, David Baker, Design of a Novel Globular Protein Fold with Atomic-Level Accuracy Science. ,vol. 302, pp. 1364- 1368 ,(2003) , 10.1126/SCIENCE.1089427
J. S. Paige, K. Y. Wu, S. R. Jaffrey, RNA Mimics of Green Fluorescent Protein Science. ,vol. 333, pp. 642- 646 ,(2011) , 10.1126/SCIENCE.1207339