Is Multiple Sclerosis a Neurodegenerative Disorder

摘要: Publisher Summary This chapter discusses the role of axonal transection and neurodegeneration in multiple sclerosis (MS). Both play significant roles MS disease progression possibility that may be a primary neurodegenerative with sec­ondary inflammatory demyelination is discussed. MS, an demyelinating central ner­vous system (CNS), affects more than 2 million people worldwide leading cause nontraumatic neurological disability young adults. The unknown clinical course variable unpredictable. chronic afflicting twice as many females males. pathologic hallmark presence demyelinated le­sions brain spinal cord white matter. employs number adoptive mecha­nisms restore function to most convinc­ing evidence demonstrating degenerative aspect unprecen­dented atrophy some patients end-stage MS. Neurodegeneration fundamental pathogenesis loss axons, dendrites, neurons major permanent neurologic patients.