Neuroendocrine Coordination of Mitochondrial Stress Signaling and Proteostasis

摘要: During neurodegenerative disease, the toxic accumulation of aggregates and misfolded proteins is often accompanied with widespread changes in peripheral metabolism, even cells which aggregating protein not present. The mechanism by central nervous system elicits a distal reaction to proteotoxic stress remains unknown. We hypothesized that endocrine communication neuronal plays causative role mitochondrial homeostasis associated disease states. find an aggregation-prone expressed neurons C. elegans binds mitochondria, eliciting global induction mitochondrial-specific unfolded response (UPRmt), affecting whole-animal physiology. Importantly, dense core vesicle release secretion neurotransmitter serotonin required for signal’s propagation. Collectively, these data suggest commandeering nutrient sensing network allow cell-to-cell between mitochondria folding system.