Phase I pharmacokinetic (PK) and pharmacodynamic (PD) study of the selective aurora A kinase (AAK) inhibitor MLN8054 in patients (pts) with advanced solid tumors
作者： T. Macarulla , E. Rodríguez-Braun , J. Tabernero , S. Roselló , J. Baselga
DOI: 10.1200/JCO.2009.27.15_SUPPL.2578
关键词: Pharmacology 、 Programmed cell death 、 Medicine 、 In patient 、 Aurora A kinase 、 Chromosome 、 Pharmacodynamics 、 Pharmacokinetics 、 Mitosis
摘要: 2578 Background: MLN8054, a first-generation, selective AAK inhibitor, induces chromosome alignment and segregation defects during mitosis, leading to cell death (Hoar et al, MolCellBio 2007;27:451...
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