Messenger Function of Serotonin in the Enteric Nervous System
作者： J. D. Wood
DOI: 10.1007/978-94-009-1912-9_31
关键词: Serotonin 、 Depolarization 、 Acetylcholine 、 Myenteric plexus 、 Excitatory postsynaptic potential 、 Nicotinic agonist 、 Enteroendocrine cell 、 Biophysics 、 Chemistry 、 Enteric nervous system
摘要: Serotonin is localized in myenteric neurons which have Dogiel I morphology the small intestine of guinea-pig. When applied to intestine, it activates intramural increase acetylcholine release, enhance contractile activity and stimulate secretion chloride ions water from intestinal crypts. Microapplication serotonin enteric ganglion cells evokes one three responses. One response a long-lasting depolarization associated with decreased potassium conductance enhanced excitability that persists for several seconds after pulse serotonin. This mimics slow excitatory postsynaptic potentials are evoked by electrical stimulation axons nervous system. The second transient spike discharge an increased membrane sodium ions. third presynaptic inhibition at nicotinic synapses on cell bodies neurons.
springer.com
sci-hub.st 参考文章(25)
M Takaki, T Branchek, H Tamir, MD Gershon, Specific antagonism of enteric neural serotonin receptors by dipeptides of 5-hydroxytryptophan: evidence that serotonin is a mediator of slow synaptic excitation in the myenteric plexus The Journal of Neuroscience. ,vol. 5, pp. 1769- 1780 ,(1985) , 10.1523/JNEUROSCI.05-07-01769.1985
Edith Bülbring, R. C. Y. Lin, The effect of intraluminal application of 5-hydroxytryptamine and 5-hydroxytryptophan on peristalsis; the local production of 5-HT and its release in relation to intraluminal pressure and propulsive activity. The Journal of Physiology. ,vol. 140, pp. 381- 407 ,(1958) , 10.1113/JPHYSIOL.1958.SP005940
JOHN M. KELLUM, BERNARD M. JAFFE, Release of immunoreactive serotonin following acid perfusion of the duodenum. Annals of Surgery. ,vol. 184, pp. 633- 636 ,(1976) , 10.1097/00000658-197611000-00018
J.B. Furness, M. Costa, Neurons with 5-hydroxytryptamine-like immunoreactivity in the enteric nervous system: Their projections in the guinea-pig small intestine Neuroscience. ,vol. 7, pp. 341- 349 ,(1982) , 10.1016/0306-4522(82)90271-8
Björn Biber Ove Lungren, Joar Svanvik, Studies on the Intestinal Vasodilatation Observed after Mechanical Stimulation of the Mucosa of the Gut Acta Physiologica Scandinavica. ,vol. 82, pp. 177- 190 ,(1971) , 10.1111/J.1748-1716.1971.TB04957.X
Paul R. Wade, Jackie D. Wood, Actions of serotonin and substance P on myenteric neurons of guinea-pig distal colon. European Journal of Pharmacology. ,vol. 148, pp. 1- 8 ,(1988) , 10.1016/0014-2999(88)90447-5
G. M. Mawe, T. A. Branchek, M. D. Gershon, Peripheral neural serotonin receptors: identification and characterization with specific antagonists and agonists. Proceedings of the National Academy of Sciences of the United States of America. ,vol. 83, pp. 9799- 9803 ,(1986) , 10.1073/PNAS.83.24.9799
Paul R. Nemeth, Carol A. Ort, Dimiter H. Zafirov, Jackie D. Wood, Interactions between serotonin and cisapride on myenteric neurons. European Journal of Pharmacology. ,vol. 108, pp. 77- 83 ,(1985) , 10.1016/0014-2999(85)90285-7
A. Surprenant, J. Crist, Electrophysiological characterization of functionally distinct 5-hydroxytryptamine receptors on guinea-pig submucous plexus. Neuroscience. ,vol. 24, pp. 283- 295 ,(1988) , 10.1016/0306-4522(88)90331-4
R.A. North, G. Henderson, Y. Katayama, S.M. Johnson, Electrophysiological evidence for presynaptic inhibition of acetylcholine release by 5-hydroxytryptamine in the enteric nervous system. Neuroscience. ,vol. 5, pp. 581- 586 ,(1980) , 10.1016/0306-4522(80)90055-X