G protein-coupled receptor rhodopsin: a prospectus.
作者： Sławomir Filipek , Ronald E. Stenkamp , David C. Teller , Krzysztof Palczewski
DOI: 10.1146/ANNUREV.PHYSIOL.65.092101.142611
关键词: Rhodopsin 、 Protein structure 、 G protein-coupled receptor 、 GTP-binding protein regulators 、 Visual phototransduction 、 Biochemistry 、 Transmembrane protein 、 Opsin 、 Biology 、 Peptide sequence
摘要: Rhodopsin is a retinal photoreceptor protein of bipartite structure consisting the transmembrane opsin and light-sensitive chromophore 11-cis-retinal, linked to via protonated Schiff base. Studies on rhodopsin have unveiled many structural functional features that are common large pharmacologically important group proteins from G protein-coupled receptor (GPCR) superfamily, which best-studied member. In this work, we focus as revealed by biochemical investigations. particular, high-resolution bovine provides template for understanding how GPCRs work. We describe sensitivity complexity lead its role in vision.
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