Visualizing peroxynitrite fluxes in endothelial cells reveals the dynamic progression of brain vascular injury.

摘要: Accumulating evidence suggests that formation of peroxynitrite (ONOO–) in the cerebral vasculature contributes to the progression of ischemic damage, while the underlying molecular mechanisms remain elusive. To fully understand ONOO–biology, efficient tools that can realize the real-time tracing of endogenous ONOO–fluxes are indispensable. While a few ONOO–fluorescent probes have been reported, direct visualization of ONOO–fluxes in the cerebral vasculature of live mice remains a challenge. Herein, we present a fluorescent …