IVIG enters the central nervous system during treatment of experimental autoimmune encephalomyelitis and is localised to inflammatory lesions
作者： Signe Humle Jorgensen , Nicolas Storm , Poul Erik Hyldgaard Jensen , Henning Laursen , Per Soelberg Sorensen
DOI: 10.1007/S00221-006-0752-8
关键词: Experimental autoimmune encephalomyelitis 、 Central nervous system 、 Central nervous system disease 、 Extravasation 、 Blood–brain barrier 、 Multiple sclerosis 、 Immune system 、 Immunology 、 Pathology 、 Nervous system 、 Medicine
摘要: Intravenous immunoglobulin (IVIG) treatment reduces the relapse rate in relapsing–remitting multiple sclerosis (MS) and may interfere with MS pathology through its various anti-inflammatory immunomodulatory properties. It is presently unknown whether IVIG enters central nervous system (CNS) sufficient amounts to influence local immune response within brain spinal cord, or if effects are entirely due peripheral actions of IVIG. The purpose present study was evaluate radiolabeled 99mTc CNS during experimental autoimmune encephalomyelitis (EAE) susceptible rat strain Dark Agouti. After vivo administration 99mTc-IVIG we observed significantly increased accumulation cord from rats EAE. Accumulation not detectable tissue control animals. In samples minor increases organ binding were liver kidney Localisation visualised by autoradiography revealed significant only areas also affected perivascular inflammation leakage serum proteins. conclusion, results indicate that extravasation occurs when blood–brain barrier function compromised
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