Teratogenic responses of zebrafish embryos to decabromodiphenyl ether (BDE-209) in the presence of nano-SiO2 particles
作者： Shu-Ju Chao , Chin Pao Huang , Pei-Chung Chen , Chihpin Huang
DOI: 10.1016/J.CHEMOSPHERE.2017.03.075
关键词: Decabromodiphenyl ether 、 Yolk sac 、 Anatomy 、 Hatching 、 Zebrafish 、 Andrology 、 Intracellular 、 Biology 、 Human fertilization 、 Extracellular 、 Embryo
摘要: This study investigated the influence of nano-SiO2 particles (nSiO2) on teratogenic responses zebrafish embryos to decabromodiphenyl ether (BDE-209). Zebrafish were exposed BDE-209 in absence and presence nSiO2 for 96 h post fertilization (hpf). Results showed that formation nSiO2-BDE-209 associates promoted both extracellular intracellular uptake by embryos, thereby increasing bioconcentration chorion surface embryos. also delay hatching temporarily when co-exposure at 60 hpf. Furthermore, there was heartbeat decline (28.3 beats/10s) increase irregular (45.8%) larvae 96 hpf, compared sole exposure (32.7 beats/10s 0%). Malformation terms spinal curvature (SC), pericardial edema (PE) yolk sac (YSE) observed 33.9, 23.4, 18%, respectively. Overall, abnormal development apparent nSiO2. All relevant evidence considered, could facilitate transport towards negatively impact zebrafish.
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