Aurora-B mediated ATM serine 1403 phosphorylation is required for mitotic ATM activation and the spindle checkpoint
作者： Chunying Yang , Xi Tang , Xiaojing Guo , Yohei Niikura , Katsumi Kitagawa
DOI: 10.1016/J.MOLCEL.2011.09.016
关键词: Spindle checkpoint 、 Kinetochore 、 Biology 、 Aurora B kinase 、 Spindle apparatus 、 BUB1 、 CHEK1 、 Aurora Kinase B 、 Cell biology 、 Mitosis
摘要: The ATM kinase plays a critical role in the maintenance of genetic stability. is activated response to DNA damage and essential for cell-cycle checkpoints. Here, we report that mitosis absence damage. We demonstrate mitotic activation dependent on Aurora-B phosphorylates serine 1403. This phosphorylation event required activation. Further, show loss function results shortened timing defective spindle checkpoint, abrogation Ser1403 leads this checkpoint defect. also mitotically Bub1, kinetochore protein, Ser314. ATM-mediated Bub1 Ser314 activity checkpoint. Collectively, our data highlight mechanisms mitosis.
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