The combination of Puerariae Lobatae Radix and Chuanxiong Rhizoma enhanced the absorption and pharmacokinetics of puerarin by modulating the intestinal barrier and influenced gut microbiota
作者： Runzhi Chen , Peng Wu , Zheng Cai , Lan Tang , Ling Ye
DOI: 10.1016/J.JFF.2018.05.043
关键词: Puerarin 、 Absorption (skin) 、 Gut flora 、 Flavonoid 、 Daidzein 、 Pharmacology 、 Pharmacokinetics 、 Daidzin 、 Intestinal absorption 、 Chemistry
摘要: Abstract Puerarin, the most important flavonoid in Puerariae Lobatae Radix (PLR), has high biological activity but poor oral absorption. This study investigated how to enhance absorption and pharmacokinetics of puerarin through modulating intestinal barrier. Analyses absorption, demonstrated enhanced with daidzin, daidzein ligustrazine (the main active ingredient vinegar Chuanxiong Rhizoma (CXR)). In particular, PLR combined CXR elevating solubility, regulating P-glycoprotein efflux reducing claudin-5 expression. The combination reduced diversity gut microbiota ratio Firmicutes Bacteroidetes. conclusion, combining by barrier influenced microbiota. is likely be a potential target for CXR.
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