作者: Bennett D Elzey , Jun Tian , Robert J Jensen , Axel K Swanson , Jason R Lees
DOI: 10.1016/S1074-7613(03)00177-8
关键词: Biology 、 B cell 、 Acquired immune system 、 Immunology 、 Hemostatic function 、 Immunoglobulin class switching 、 CD154 、 Immune system 、 Dendritic cell 、 Cell biology 、 T cell
摘要: Platelets are highly reactive components of the circulatory system with well-documented hemostatic function. Recent studies extend platelet function to modulation local inflammatory events through release chemokines, cytokines, and a number immunomodulatory ligands, including CD154. We hypothesized that platelet-derived CD154 modulates adaptive immunity. The data reported herein demonstrate platelets, via CD154, induce dendritic cell maturation, B isotype switching, augment CD8(+) T responses both in vitro vivo. Platelet transfusion alone is sufficient switching lymphocyte during viral infection, leading enhanced protection against rechallenge. Additionally, depletion platelets normal mice results decreased antigen-specific antibody production.