Hold your horses: impulsivity, deep brain stimulation, and medication in parkinsonism.
作者： M. J. Frank , J. Samanta , A. A. Moustafa , S. J. Sherman
关键词: Deep brain stimulation 、 Impulsivity 、 Basal ganglia 、 Dopamine dysregulation syndrome 、 Cognitive disorder 、 Dopaminergic 、 Subthalamic nucleus 、 Parkinsonism 、 Neuroscience 、 Medicine
摘要: Deep brain stimulation (DBS) of the subthalamic nucleus markedly improves motor symptoms Parkinson's disease, but causes cognitive side effects such as impulsivity. We showed that DBS selectively interferes with normal ability to slow down when faced decision conflict. While on DBS, patients actually sped up their decisions under high-conflict conditions. This form impulsivity was not affected by dopaminergic medication status. Instead, impaired patients' learn from negative outcomes. These findings implicate independent mechanisms leading in treated and were predicted a single neurocomputational model basal ganglia.
sciencemag.org
harvard.edu
elsevier.com
brown.edu 参考文章(34)
Matthew Botvinick, Leigh E. Nystrom, Kate Fissell, Cameron S. Carter, Jonathan D. Cohen, Conflict monitoring versus selection-for-action in anterior cingulate cortex Nature. ,vol. 402, pp. 179- 181 ,(1999) , 10.1038/46035
Christelle Baunez, Anastasia Christakou, Yogita Chudasama, Claude Forni, Trevor W. Robbins, Bilateral high-frequency stimulation of the subthalamic nucleus on attentional performance: transient deleterious effects and enhanced motivation in both intact and parkinsonian rats. European Journal of Neuroscience. ,vol. 25, pp. 1187- 1194 ,(2007) , 10.1111/J.1460-9568.2007.05373.X
Michael J. Frank, Dynamic Dopamine Modulation in the Basal Ganglia: A Neurocomputational Account of Cognitive Deficits in Medicated and Nonmedicated Parkinsonism Journal of Cognitive Neuroscience. ,vol. 17, pp. 51- 72 ,(2005) , 10.1162/0898929052880093
M. Leann Dodd, Kevin J. Klos, James H. Bower, Yonas E. Geda, Keith A. Josephs, J. Eric Ahlskog, Pathological gambling caused by drugs used to treat Parkinson disease. JAMA Neurology. ,vol. 62, pp. 1377- 1381 ,(2005) , 10.1001/ARCHNEUR.62.9.NOC50009
Roger Ratcliff, Trisha Van Zandt, Gail McKoon, Connectionist and diffusion models of reaction time. Psychological Review. ,vol. 106, pp. 261- 300 ,(1999) , 10.1037/0033-295X.106.2.261
JONATHAN W MINK, The basal ganglia: focused selection and inhibition of competing motor programs. Progress in Neurobiology. ,vol. 50, pp. 381- 425 ,(1996) , 10.1016/S0301-0082(96)00042-1
Michael J. Frank, Hold your horses: a dynamic computational role for the subthalamic nucleus in decision making Neural Networks. ,vol. 19, pp. 1120- 1136 ,(2006) , 10.1016/J.NEUNET.2006.03.006
Stéphane Thobois, Gary R Hotton, Serge Pinto, Leonora Wilkinson, Patricia Limousin-Dowsey, David J Brooks, Marjan Jahanshahi, STN Stimulation Alters Pallidal—Frontal Coupling during Response Selection under Competition Journal of Cerebral Blood Flow and Metabolism. ,vol. 27, pp. 1173- 1184 ,(2007) , 10.1038/SJ.JCBFM.9600425
Alim Louis Benabid, Deep brain stimulation for Parkinson's disease. Current Opinion in Neurobiology. ,vol. 13, pp. 696- 706 ,(2003) , 10.1016/J.CONB.2003.11.001
M. J. Frank, A. A. Moustafa, H. M. Haughey, T. Curran, K. E. Hutchison, Genetic triple dissociation reveals multiple roles for dopamine in reinforcement learning Proceedings of the National Academy of Sciences of the United States of America. ,vol. 104, pp. 16311- 16316 ,(2007) , 10.1073/PNAS.0706111104