Molecular Biological Mechanisms in Photodynamic Therapy

摘要: Cellular and molecular photodamage mechanisms are initiated by light-activation of a photosensitizer following its accumulation in cellular targets. While lethal doses photodynamic therapy (PDT) eliminate vessels cells, sublethal effects occur, e.g., during fluorescence diagnosis (FD). Accordingly, the events subsequent photoactivation lead to different endpoints being primarily growth stimulation, damage repair, autophagy, apoptosis, necrosis. Activation survival pathways seems be not only involved but also PDT transmission. Sublethal results from activation protection adaptive mechanisms, can modulate signaling immune reactions. Autophagy may serve rescue cells or cell death under special conditions. Lethal activates stress response, via mitochondria ER, inducing apoptosis. If is too severe, energy level low plasma membrane leaky, will die