The peroxisome proliferator-activated receptor-γ is a negative regulator of macrophage activation

作者: Mercedes Ricote , Andrew C. Li , Timothy M. Willson , Carolyn J. Kelly , Christopher K. Glass

DOI: 10.1038/34178

关键词: Nuclear receptorGlucose homeostasisProstaglandin D2Cell signalingTranscription factorBiochemistryPeroxisome proliferator-activated receptorBiologyCyclopentenone prostaglandinsSignal transduction

摘要: … physiological ligands of PPAR-γ in adipose tissue 9 , our results suggest that PPAR-γ is regulated by distinct classes of ligands in different locations. PPAR-γ is under the transcriptional …

参考文章(26)
Timothy M. Willson, Jeffery E. Cobb, David J. Cowan, Robert W. Wiethe, Itzela D. Correa, Shimoga R. Prakash, Kelli D. Beck, Linda B. Moore, Steven A. Kliewer, Jürgen M. Lehmann, The structure - Activity relationship between peroxisome proliferator-activated receptor γ agonism and the antihyperglycemic activity of thiazolidinediones Journal of Medicinal Chemistry. ,vol. 39, pp. 665- 668 ,(1996) , 10.1021/JM950395A
Jürgen M. Lehmann, Linda B. Moore, Tracey A. Smith-Oliver, William O. Wilkison, Timothy M. Willson, Steven A. Kliewer, An Antidiabetic Thiazolidinedione Is a High Affinity Ligand for Peroxisome Proliferator-activated Receptor γ (PPARγ) Journal of Biological Chemistry. ,vol. 270, pp. 12953- 12956 ,(1995) , 10.1074/JBC.270.22.12953
C. J. Lowenstein, E. W. Alley, P. Raval, A. M. Snowman, S. H. Snyder, S. W. Russell, W. J. Murphy, Macrophage nitric oxide synthase gene: two upstream regions mediate induction by interferon gamma and lipopolysaccharide Proceedings of the National Academy of Sciences of the United States of America. ,vol. 90, pp. 9730- 9734 ,(1993) , 10.1073/PNAS.90.20.9730
Steven A. Kliewer, James M. Lenhard, Timothy M. Willson, Inder Patel, David C. Morris, Jürgen M. Lehmann, A prostaglandin J2 metabolite binds peroxisome proliferator-activated receptor γ and promotes adipocyte differentiation Cell. ,vol. 83, pp. 813- 819 ,(1995) , 10.1016/0092-8674(95)90194-9
H G Welgus, E J Campbell, J D Cury, A Z Eisen, R M Senior, S M Wilhelm, G I Goldberg, Neutral metalloproteinases produced by human mononuclear phagocytes. Enzyme profile, regulation, and expression during cellular development. Journal of Clinical Investigation. ,vol. 86, pp. 1496- 1502 ,(1990) , 10.1172/JCI114867
A. E. Horvai, L. Xu, E. Korzus, G. Brard, D. Kalafus, T.-M. Mullen, D. W. Rose, M. G. Rosenfeld, C. K. Glass, Nuclear integration of JAK/STAT and Ras/AP-1 signaling by CBP and p300 Proceedings of the National Academy of Sciences of the United States of America. ,vol. 94, pp. 1074- 1079 ,(1997) , 10.1073/PNAS.94.4.1074
Lynn M. Matrisian, The matrix-degrading metalloproteinases BioEssays. ,vol. 14, pp. 455- 463 ,(1992) , 10.1002/BIES.950140705
S. A. Kliewer, B. M. Forman, B. Blumberg, E. S. Ong, U. Borgmeyer, D. J. Mangelsdorf, K. Umesono, R. M. Evans, Differential expression and activation of a family of murine peroxisome proliferator-activated receptors Proceedings of the National Academy of Sciences of the United States of America. ,vol. 91, pp. 7355- 7359 ,(1994) , 10.1073/PNAS.91.15.7355
W. Wahli, T. M. Willson, J. M. Lenhard, J. M. Lehmann, S. A. Kliewer, S. S. Sundseth, S. A. Jones, P. J. Brown, G. B. Wisely, C. S. Koble, P. Devchand, Fatty acids and eicosanoids regulate gene expression through direct interactions with peroxisome proliferator-activated receptors α and γ Proceedings of the National Academy of Sciences of the United States of America. ,vol. 94, pp. 4318- 4323 ,(1997) , 10.1073/PNAS.94.9.4318