The Immunosuppressive Action of Gliotoxin and Related Epipolythiodioxopipderazines

作者: Arno Mullbacher , Ronald D. Eichner , Paul Waring

DOI: 10.1007/978-1-4613-0663-4_36

关键词: StereochemistryChemistryGraft rejectionGliotoxin

摘要: The epipolythiodioxopiperazines (ETP) including gliotoxin (GT) are a class of secondary fungal metabolites with bridged polysulfide ring structure as their common distinctive feature (Figure 1). Early studies these unusual compounds concentrated on anti-microbial properties and possible anti-tumor activities. These early have been extensively reviewed.14,16

参考文章(15)
Vladimir Betina, Mycotoxins; production, isolation, separation and purification Developments in food science. ,(1984)
Frederick Grinnell, Cellular adhesiveness and extracellular substrata. International Review of Cytology-a Survey of Cell Biology. ,vol. 53, pp. 65- 144 ,(1978) , 10.1016/S0074-7696(08)62241-X
Arno Müllbacher, Alvin F. Moreland, Paul Waring, Alan Sjaarda, Ronald D. Eichner, Prevention of graft-versus-host disease by treatment of bone marrow with gliotoxin in fully allogeneic chimeras and their cytotoxic T cell repertoire. Transplantation. ,vol. 46, pp. 120- 125 ,(1988) , 10.1097/00007890-198807000-00022
WILTON A. RIGHTSEL, HORST G. SCHNEIDER, BERNARD J. SLOAN, PERSIS R. GRAF, FRANCIS A. MILLER, QUENTIN R. BARTZ, JOHN EHRLICH, GLEN J. DIXON, ANTIVIRAL ACTIVITY OF GLIOTOXIN AND GLIOTOXIN ACETATE. Nature. ,vol. 204, pp. 1333- 1334 ,(1964) , 10.1038/2041333B0
AW Thomson, Immunobiology of cyclosporin A--a review. Immunology and Cell Biology. ,vol. 61, pp. 147- 172 ,(1983) , 10.1038/ICB.1983.14
Arno Müllbacher, Paul Waring, Uma Tiwari-Palni, Ronald D. Eichner, Structural relationship of epipolythiodioxopiperazines and their immunomodulating activity. Molecular Immunology. ,vol. 23, pp. 231- 235 ,(1986) , 10.1016/0161-5890(86)90047-7
R.D. Eichner, M. Al Salami, P.R. Wood, A. Müllbacher, The effect of gliotoxin upon macrophage function International Journal of Immunopharmacology. ,vol. 8, pp. 789- 797 ,(1986) , 10.1016/0192-0561(86)90016-0
Ronald D Eichner, Arno Müllbacher, Hypothesis: fungal toxins are involved in aspergillosis and AIDS Immunology and Cell Biology. ,vol. 62, pp. 479- 484 ,(1984) , 10.1038/ICB.1984.45
Antony W. Braithwaite, Ronald D. Eichner, Paul Waring, Arno Müllbacher, The immunomodulating agent gliotoxin causes genomic DNA fragmentation Molecular Immunology. ,vol. 24, pp. 47- 55 ,(1987) , 10.1016/0161-5890(87)90110-6
T.William Jordan, Stephen J. Cordiner, Fungal epipolythiodioxopiperazine toxins have therapeutic potential and roles in disease Trends in Pharmacological Sciences. ,vol. 8, pp. 144- 149 ,(1987) , 10.1016/0165-6147(87)90184-2