AKT1 G205T genotype influences obesity-related metabolic phenotypes and their responses to aerobic exercise training in older Caucasians

摘要: As part of the insulin signalling pathway, Akt influences growth and metabolism. The AKT1 gene G205T (rs1130214) polymorphism has potential functional effects. Thus, we determined whether metabolic variables their responses to aerobic exercise training. Following dietary stabilization, healthy, sedentary, 50- 75-year-old Caucasian men (n = 51) women 58) underwent 6 months Before after completing intervention, dual-energy X-ray absorptiometry was used measure percentage body fat, computed tomography visceral subcutaneous oral glucose tolerance testing total area under curve (AUC), AUC sensitivity. Taqman assay determine genotypes. At baseline, with GG genotype 29) had lower maximal oxygen consumption (VO2 max) values (P 0.026) higher fat 0.046), 0.021) 0.003) than T allele carriers 22). Despite rather disadvantageous starting values, seemed respond training more robustly allele, highlighted by significantly greater fold change improvements in 0.012) 0.035). Although group also improved VO2 max training, not as great that 0.037). In contrast, accounting for hormone replacement therapy use, none differed at baseline. a result 20) fasting 0.011), 0.017) sensitivity 0.044) 38). Our results suggest older, previously sedentary individuals.