Biological interactions of biocompatible and water-dispersed MoS 2 nanosheets with bacteria and human cells

摘要: Two dimensional materials beyond graphene such as MoS2 and WS2 are novel interesting class of whose unique physico-chemical properties can be exploited in applications ranging from leading edge nanoelectronics to the frontiers between biomedicine biotechnology. To unravel potential TMD crystals biomedicine, control over their production through green scalable routes biocompatible solvents is critically important. Furthermore, considering multiple eco-friendly 2D dispersions impact onto live matter, toxicity antimicrobial activity still remain an open issue. Herein, we focus on current demands TMDs produce high-quality, few-layered defect-free nanosheets, exfoliated dispersed pure water, stabilized up three weeks. Hence, studied this material human cells by investigating its interactions with cell lines: two tumoral, MCF7 (breast cancer) U937 (leukemia), one normal, HaCaT (epithelium). We observed intriguing results, exhibiting evident cytotoxic effect induced tumor lines, absent normal tested conditions. The antibacterial action nanosheets then investigated against a very dangerous gram negative bacterium, types Salmonellas: ATCC 14028 wild-type Salmonella typhimurium. Additionally, concentration layer-dependent modulation found both Salmonellas.