The Phosphine-Catalyzed Alkyneto 1,3-Diene Isomerization Reaction

摘要: The alkyne to 1,3-diene isomerization reaction is a process in which nucleophilic phosphine catalyst promotes the rearrangement of an electron-withdrawing group activated corresponding conjugated diene. origin, mechanism, development, and application of this organocatalytic stereoselective in synthesis of complex organic molecules are reviewed. 1 Introduction 2 The Reaction 2.1 Background 2.2 Mechanism 2.3 Development 2.4 Synthetic Applications 3 Conclusions