MicroRNAs driving invasion and metastasis in ovarian cancer: Opportunities for translational medicine (Review)
作者： Carlos Palma Flores , Raúl García-Vázquez , Dolores Gallardo Rincón , Erika Ruiz-García , Horacio Astudillo De La Vega
关键词: Translational research 、 Cancer research 、 Molecular medicine 、 Oncology 、 Oncogene 、 Cancer 、 Translational medicine 、 Biology 、 Internal medicine 、 Ovarian cancer 、 Metastasis 、 microRNA
摘要: Epithelial ovarian cancer is the fifth most frequent cause of death in women. In spite advantages early detection and treatment options, overall survival rates have improved only slightly last decades. Therefore, alternative therapeutic approaches need to overcome resistance improve patient outcome. MicroRNAs are evolutionary conserved small non-coding RNAs that function as negative regulators gene expression by inhibiting translation or inducing degradation messenger RNAs. cancer, microRNAs aberrantly expressed thus representing potential prognostic biomarkers novel targets. The knowledge unexpected functions rapidly evolving advance elucidation clinical applications deserves attention. Recently, a specific set dubbed metastamiRs been shown initiate invasion metastasis diverse types cancer. We reviewed current status development progression with special emphasis on tumor cells metastasis. Also, we show an update microRNA oncogenic pathways discuss scenario for translational research
sci-hub.se 参考文章(143)
SHAORU LI, YAN LI, ZHENGFANG WEN, FANJING KONG, XINLEI GUAN, WENHUI LIU, microRNA‑206 overexpression inhibits cellular proliferation and invasion of estrogen receptor α‑positive ovarian cancer cells Molecular Medicine Reports. ,vol. 9, pp. 1703- 1708 ,(2014) , 10.3892/MMR.2014.2021
Thordur Oskarsson, Eduard Batlle, Joan Massagué, Metastatic stem cells: sources, niches, and vital pathways. Cell Stem Cell. ,vol. 14, pp. 306- 321 ,(2014) , 10.1016/J.STEM.2014.02.002
Chang-Il Hwang, Jinhyang Choi, Zongxiang Zhou, Andrea Flesken-Nikitin, Alexander Tarakhovsky, Alexander Y. Nikitin, MET-dependent cancer invasion may be preprogrammed by early alterations of p53-regulated feedforward loop and triggered by stromal cell-derived HGF. Cell Cycle. ,vol. 10, pp. 3834- 3840 ,(2011) , 10.4161/CC.10.22.18294
Kai Doberstein, Niko P. Bretz, Uwe Schirmer, Heidi Fiegl, Roman Blaheta, Christian Breunig, Elisabeth Müller-Holzner, Dan Reimer, Alain G. Zeimet, Peter Altevogt, miR-21-3p is a positive regulator of L1CAM in several human carcinomas Cancer Letters. ,vol. 354, pp. 455- 466 ,(2014) , 10.1016/J.CANLET.2014.08.020
Souriya Vang, Hsin-Ta Wu, Andrew Fischer, Daniel H. Miller, Shannon MacLaughlan, Elijah Douglass, Margaret Steinhoff, Colin Collins, Peter J. S. Smith, Laurent Brard, Alexander S. Brodsky, Identification of Ovarian Cancer Metastatic miRNAs PLoS ONE. ,vol. 8, pp. e58226- ,(2013) , 10.1371/JOURNAL.PONE.0058226
Shujun Feng, Wenjing Pan, Ye Jin, Jianhua Zheng, MiR-25 promotes ovarian cancer proliferation and motility by targeting LATS2. Tumor Biology. ,vol. 35, pp. 12339- 12344 ,(2014) , 10.1007/S13277-014-2546-0
Wenxing Qin, Qiusheng Ren, Te Liu, Yongyi Huang, Jiejun Wang, MicroRNA-155 is a novel suppressor of ovarian cancer-initiating cells that targets CLDN1. FEBS Letters. ,vol. 587, pp. 1434- 1439 ,(2013) , 10.1016/J.FEBSLET.2013.03.023
Da Yang, Yan Sun, Limei Hu, Hong Zheng, Ping Ji, Chad V Pecot, Yanrui Zhao, Sheila Reynolds, Hanyin Cheng, Rajesha Rupaimoole, David Cogdell, Matti Nykter, Russell Broaddus, Cristian Rodriguez-Aguayo, Gabriel Lopez-Berestein, Jinsong Liu, Ilya Shmulevich, Anil K Sood, Kexin Chen, Wei Zhang, None, Integrated analyses identify a master microRNA regulatory network for the mesenchymal subtype in serous ovarian cancer Cancer Cell. ,vol. 23, pp. 186- 199 ,(2013) , 10.1016/J.CCR.2012.12.020
Xin Lu, Tiam1, negatively regulated by miR-22, miR-183 and miR-31, is involved in migration, invasion and viability of ovarian cancer cells Oncology Reports. ,vol. 27, pp. 1835- 1842 ,(2012) , 10.3892/OR.2012.1744
Xiaofei Xu, Bushra Ayub, Zhaojian Liu, Vanida Ann Serna, Wenan Qiang, Yugang Liu, Eva Hernando, Sonya Zabludoff, Takeshi Kurita, Beihua Kong, Jian-Jun Wei, Anti-miR182 Reduces Ovarian Cancer Burden, Invasion, and Metastasis: An In Vivo Study in Orthotopic Xenografts of Nude Mice Molecular Cancer Therapeutics. ,vol. 13, pp. 1729- 1739 ,(2014) , 10.1158/1535-7163.MCT-13-0982