Palladium(0)-catalyzed [2 + 2 + 1] cyclization of 1,6-enynes with vinyl bromides: a highly diastereoselective synthesis of tetrahydro-1H-cyclopenta[c]furans bearing two quaternary carbon centers
作者： Yunxia Diao , Zhijun Zuo , Hui Wang , Jingjing Liu , Xinjun Luan
DOI: 10.1039/C7OB00768J
关键词: Catalysis 、 Medicinal chemistry 、 Palladium 、 Quaternary carbon 、 Chemistry 、 Organic chemistry
摘要: A new cascade process has been accomplished for the synthesis of tetrahydro-1H-cyclopenta[c]furans through palladium-catalyzed [2 + 2 1] cyclization 1,6-enynes with vinyl bromides. Notably, key feature this transformation is use bromides as C1 building block. Various functionalized bearing two quaternary carbon centers could be obtained in good yields excellent diastereoselectivities.
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