Chemokines and Bone.
DOI: 10.1007/164_2020_349
关键词: Osteoclast 、 Osteoimmunology 、 Chemokine 、 Hematopoietic stem cell 、 Osteoblast 、 G protein-coupled receptor 、 Biology 、 Cancer research 、 Chemokine receptor 、 Angiogenesis
摘要: Chemokines are a family of small proteins, subdivided by their conserved cysteine residues and common structural features. interact with cognate G-protein-coupled receptors to elicit downstream signals that result in cell migration, proliferation, survival. This review presents evidence for how the various CXC CC subfamily chemokines influence bone hemostasis acting on osteoclasts, osteoblasts, progenitor cells. Also discussed ways which contribute loss as inflammatory diseases such rheumatoid arthritis, HIV infection, periodontal infection. Both positive negative effects formation presented. In addition, role altering microenvironment through angiogenesis tumor invasion is discussed. Very few therapeutic agents targeting or chemokine available, although currently being evaluated.
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Alan P Molloy, Fiachra T Martin, Roisin M Dwyer, Tomas P Griffin, Mary Murphy, Frank P Barry, Timothy O'Brien, Michael J Kerin, None, Mesenchymal stem cell secretion of chemokines during differentiation into osteoblasts, and their potential role in mediating interactions with breast cancer cells International Journal of Cancer. ,vol. 124, pp. 326- 332 ,(2009) , 10.1002/IJC.23939
Theresa L Chen, Inhibition of growth and differentiation of osteoprogenitors in mouse bone marrow stromal cell cultures by increased donor age and glucocorticoid treatment Bone. ,vol. 35, pp. 83- 95 ,(2004) , 10.1016/J.BONE.2004.03.019
Ariane L. Jansma, John P. Kirkpatrick, Andro R. Hsu, Tracy M. Handel, Daniel Nietlispach, NMR Analysis of the Structure, Dynamics, and Unique Oligomerization Properties of the Chemokine CCL27 Journal of Biological Chemistry. ,vol. 285, pp. 14424- 14437 ,(2010) , 10.1074/JBC.M109.091108
Peter M. Govey, Jon M. Jacobs, Susan C. Tilton, Alayna E. Loiselle, Yue Zhang, Willard M. Freeman, Katrina M. Waters, Norman J. Karin, Henry J. Donahue, Integrative Transcriptomic and Proteomic Analysis of Osteocytic Cells Exposed to Fluid Flow Reveals Novel Mechano-Sensitive Signaling Pathways Journal of Biomechanics. ,vol. 47, pp. 1838- 1845 ,(2014) , 10.1016/J.JBIOMECH.2014.03.022
Michael S. Valerio, Bethany A. Herbert, Dimitrios S. Basilakos, Courtney Browne, Hong Yu, Keith L. Kirkwood, Critical role of MKP-1 in lipopolysaccharide-induced osteoclast formation through CXCL1 and CXCL2. Cytokine. ,vol. 71, pp. 71- 80 ,(2015) , 10.1016/J.CYTO.2014.08.007
M-J Jung, J-K Rho, Y-M Kim, J E Jung, Y B Jin, Y-G Ko, J-S Lee, S-J Lee, J C Lee, M-J Park, Upregulation of CXCR4 is functionally crucial for maintenance of stemness in drug-resistant non-small cell lung cancer cells. Oncogene. ,vol. 32, pp. 209- 221 ,(2013) , 10.1038/ONC.2012.37
Axel Vater, Sven Klussmann, Turning mirror-image oligonucleotides into drugs: the evolution of Spiegelmer(®) therapeutics. Drug Discovery Today. ,vol. 20, pp. 147- 155 ,(2015) , 10.1016/J.DRUDIS.2014.09.004
Daniel Lundell, Joseph Kozlowski, Seong Heon Kim, David Kinsley, Long Cui, Eva Pia Reich, Mary Ann Cox, Lee Sullivan, Shu Cheng Chen, Shiguang Qian, Shiguang Qian, Chung Her Jenh, Jay S. Fine, Jay S. Fine, Paul J. Zavodny, Stuart Rosenblum, A selective and potent CXCR3 antagonist SCH 546738 attenuates the development of autoimmune diseases and delays graft rejection BMC Immunology. ,vol. 13, pp. 2- 2 ,(2012) , 10.1186/10.1186/1471-2172-13-2
Min Ren, Qing Guo, Liang Guo, Martin Lenz, Feng Qian, Rory R Koenen, Hua Xu, Alexander B Schilling, Christian Weber, Richard D Ye, Aaron R Dinner, Wei-Jen Tang, Polymerization of MIP-1 chemokine (CCL3 and CCL4) and clearance of MIP-1 by insulin-degrading enzyme The EMBO Journal. ,vol. 29, pp. 3952- 3966 ,(2010) , 10.1038/EMBOJ.2010.256
Michael S. Kim, Christopher J. Day, Nigel A. Morrison, MCP-1 Is Induced by Receptor Activator of Nuclear Factor-κB Ligand, Promotes Human Osteoclast Fusion, and Rescues Granulocyte Macrophage Colony-stimulating Factor Suppression of Osteoclast Formation Journal of Biological Chemistry. ,vol. 280, pp. 16163- 16169 ,(2005) , 10.1074/JBC.M412713200