BRAFV600E and BRAF-inactivating mutations in NSCLC

Anirudh Prahallad, Guus J.J.E. Heynen, Giovanni Germano, Stefan M. Willems, Bastiaan Evers, Loredana Vecchione, Valentina Gambino, Cor Lieftink, Roderick L. Beijersbergen, Federica Di Nicolantonio, Alberto Bardelli, Rene Bernards, PTPN11 Is a Central Node in Intrinsic and Acquired Resistance to Targeted Cancer Drugs Cell Reports. ,vol. 12, pp. 1978- 1985 ,(2014) , 10.1016/J.CELREP.2015.08.037

Maria R. Girotti, Malin Pedersen, Berta Sanchez-Laorden, Amaya Viros, Samra Turajlic, Dan Niculescu-Duvaz, Alfonso Zambon, John Sinclair, Andrew Hayes, Martin Gore, Paul Lorigan, Caroline Springer, James Larkin, Claus Jorgensen, Richard Marais, Inhibiting EGF Receptor or SRC Family Kinase Signaling Overcomes BRAF Inhibitor Resistance in Melanoma Cancer Discovery. ,vol. 3, pp. 158- 167 ,(2013) , 10.1158/2159-8290.CD-12-0386

Dana Neel, Jenny Jiacheng Yan, Xinyuan Lu, Luu Pham, Mingxue M Wang, Niki Karachaliou, Maria Gonzalez Cao, Jose Luis Manzano, Jose Luis Ramirez, Jose Miguel Sanchez Torres, Fiamma Buttitta, Charles M Rudin, Eric A Collisson, Alain Algazi, Eric Robinson, Iman Osman, Eva Muñoz-Couselo, Javier Cortes, Dennie T Frederick, Zachary A Cooper, Martin McMahon, Antonio Marchetti, Rafael Rosell, Keith T Flaherty, Jennifer A Wargo, Trever G Bivona, Luping Lin, Amit J Sabnis, Elton Chan, Victor Olivas, Lindsay Cade, Evangelos Pazarentzos, Saurabh Asthana, The Hippo effector YAP promotes resistance to RAF- and MEK-targeted cancer therapies Nature Genetics. ,vol. 47, pp. 250- 256 ,(2015) , 10.1038/NG.3218

L. Lin, S. Asthana, E. Chan, S. Bandyopadhyay, M. M. Martins, V. Olivas, J. J. Yan, L. Pham, M. M. Wang, G. Bollag, D. B. Solit, E. A. Collisson, C. M. Rudin, B. S. Taylor, T. G. Bivona, Mapping the molecular determinants of BRAF oncogene dependence in human lung cancer Proceedings of the National Academy of Sciences of the United States of America. ,vol. 111, ,(2014) , 10.1073/PNAS.1320956111

David Planchard, Tae Min Kim, Julien Mazieres, Elisabeth Quoix, Gregory Riely, Fabrice Barlesi, Pierre-Jean Souquet, Egbert F Smit, Harry J M Groen, Ronan J Kelly, B C Cho, Mark A Socinski, Lini Pandite, Christine Nase, Bo Ma, Anthony D'Amelio, Bijoyesh Mookerjee, C Martin Curtis, Bruce E Johnson, Dabrafenib in patients with BRAF(V600E)-positive advanced non-small-cell lung cancer: a single-arm, multicentre, open-label, phase 2 trial. Lancet Oncology. ,vol. 17, pp. 642- 650 ,(2016) , 10.1016/S1470-2045(16)00077-2

David Planchard, Egbert F Smit, Harry J M Groen, Julien Mazieres, Benjamin Besse, Åslaug Helland, Vanessa Giannone, Anthony M D'Amelio, Pingkuan Zhang, Bijoyesh Mookerjee, Bruce E Johnson, Dabrafenib plus trametinib in patients with previously untreated BRAFV600E-mutant metastatic non-small-cell lung cancer: an open-label, phase 2 trial The Lancet Oncology. ,vol. 18, pp. 1307- 1316 ,(2017) , 10.1016/S1470-2045(17)30679-4

Amir Noeparast, Erik Teugels, Philippe Giron, Gil Verschelden, Sylvia De Brakeleer, Lore Decoster, Jacques De Grève, Non-V600 BRAF mutations recurrently found in lung cancer predict sensitivity to the combination of Trametinib and Dabrafenib Oncotarget. ,vol. 8, pp. 60094- 60108 ,(2017) , 10.18632/ONCOTARGET.11635

Yaohua Xue, Luciano Martelotto, Timour Baslan, Alberto Vides, Martha Solomon, Trang Thi Mai, Neelam Chaudhary, Greg J Riely, Bob T Li, Kerry Scott, Fabiola Cechhi, Ulrika Stierner, Kalyani Chadalavada, Elisa de Stanchina, Sarit Schwartz, Todd Hembrough, Gouri Nanjangud, Michael F Berger, Jonas Nilsson, Scott W Lowe, Jorge S Reis-Filho, Neal Rosen, Piro Lito, An approach to suppress the evolution of resistance in BRAFV600E-mutant cancer Nature Medicine. ,vol. 23, pp. 929- 937 ,(2017) , 10.1038/NM.4369

Patricia Nieto, Chiara Ambrogio, Laura Esteban-Burgos, Gonzalo Gómez-López, María Teresa Blasco, Zhan Yao, Richard Marais, Neal Rosen, Roberto Chiarle, David G. Pisano, Mariano Barbacid, David Santamaría, A Braf kinase-inactive mutant induces lung adenocarcinoma Nature. ,vol. 548, pp. 239- 243 ,(2017) , 10.1038/NATURE23297

David Planchard, Benjamin Besse, Harry J M Groen, Pierre-Jean Souquet, Elisabeth Quoix, Christina S Baik, Fabrice Barlesi, Tae Min Kim, Julien Mazieres, Silvia Novello, James R Rigas, Allison Upalawanna, Anthony M D'Amelio, Pingkuan Zhang, Bijoyesh Mookerjee, Bruce E Johnson, Dabrafenib plus trametinib in patients with previously treated BRAFV600E-mutant metastatic non-small cell lung cancer: an open-label, multicentre phase 2 trial The Lancet Oncology. ,vol. 17, pp. 984- 993 ,(2016) , 10.1016/S1470-2045(16)30146-2