The quest to understand heterotrimeric G protein signaling
作者： John J G Tesmer
DOI: 10.1038/NSMB0610-650
关键词: G beta-gamma complex 、 G protein-coupled receptor kinase 、 Heterotrimeric G protein 、 G protein-coupled receptor 、 Cell biology 、 G protein 、 cAMP-dependent pathway 、 Biology 、 GTPase-activating protein 、 G12/G13 alpha subunits 、 Molecular biology 、 Structural biology
摘要: Over the past fifteen years, great strides have been made to understand molecular basis of how heterotrimeric G proteins control activity their downstream targets. However, mechanism by which are activated upstream protein-coupled receptors remains obscure. Recent structural data provides more insight into this process and supports idea that GPCRs, despite small size, sophisticated allosteric machines with multiple signaling outputs.
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