A Structural Analysis of Glycosaminoglycans from Lethal and Nonlethal Breast Cancer Tissues: Toward a Novel Class of Theragnostics for Personalized Medicine in Oncology?
作者： Amanda Weyers , Bo Yang , Dae Sung Yoon , Jong-Hwan Park , Fuming Zhang
关键词: Chain length 、 Biology 、 Oncology 、 Cancer 、 Normal tissue 、 Personalized medicine 、 Sulfation 、 Internal medicine 、 Glycosaminoglycan 、 Breast cancer 、 Response to treatment
摘要: Abstract Cancer is one of the leading noncommunicable diseases that vastly impacts both developed and developing countries. Truly innovative diagnostics inform disease susceptibility, prognosis, and/or response to treatment (theragnostics) are seriously needed for global public health personalized medicine patients with cancer. This study examined structure content glycosaminoglycans (GAGs) in lethal nonlethal breast cancer tissues from six patients. The glycosaminoglycan isolated tissue containing tumors was approximately twice other tissues. Molecular weight analysis showed cancerous had a longer average chain length by an five disaccharide units, increase 15%. Dissacharide found differences sulfation patterns between normal tissues, as well GAG chains Specifi...
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