Influence of dexamethasone on atrial ion currents and their early ionic tachycardia-induced electrical remodeling in rabbits.
作者： Roman Laszlo , Mareike Schwiebert , Karen Anna Menzel , Birgit Schreiner , Christian Eick
DOI: 10.1159/000322317
关键词: Pathophysiology 、 Atrial pacing 、 Electrical Remodeling 、 Internal medicine 、 Inflammation 、 Dexamethasone 、 Atrial fibrillation 、 Medicine 、 Patch clamp 、 Tachycardia 、 Endocrinology
摘要: Background: Certain evidence points to a role of inflammation in AF pathophysiology. Thus, antiinflammatory treatment is discussed. Effects dexamethasone (7 days) on atrial ion currents (ICa,L, Ito, Isus) and their tachycardia-induced remodeling were studied rabbit model. Methods: 6 groups 4 animals each built. Rapid pacing (600 min) was performed for 24 120 hours with/ without treatment. Ion measured using whole cell patch clamp method. Results: reduced Ito decreased after but almost returned control values hours. When dexamethasone-treated also underwent tachypacing, pacing-induced reduction ICa,L still observed even augmented compared untreated tachypaced animals. not influenced by alone. In animals, occurred tachypacing. Isus neither rapid nor dexamethasone. Biophysical properties all affected Conclusion: Dexamethasone alterations Ito. Our experiments give that - amongst other anti-inflammatory action – impact might play treatment/prevention with steroids.
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