Effect of maternal cadmium exposure on postnatal development and tissue cadmium, copper and zinc concentrations in rats
作者： Boguslaw Barański
DOI: 10.1007/BF00297116
关键词: Endocrinology 、 Weaning 、 Metabolism 、 Offspring 、 Cadmium 、 Gestation 、 Internal medicine 、 Zinc 、 Hemoglobin 、 Biology 、 Hematocrit
摘要: Administration of 60 ppm cadmium (Cd) in drinking water from the 1st to 20th day gestation female rats did not affect viability, body weight gain, food, and consumption offspring. The blood hemoglobin level was reduced 2-week-old females males but 16-week-old Hematocrit serum glucose were affected at either age. Cadmium concentration intestinal wall increased both age groups, with marginal uptake other organs. A decrease copper (Cu) found brain offspring sexes females. zinc (Zn) decreased only animals. physical neuromuscular development before weaning impaired by maternal Cd treatment. alterations Cu Zn metabolism associated locomotor activity open-field behavior adult sex avoidance acquisition results obtained suggest a relationship between levels CNS dysfunction exposed during gestation.
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