Microbial colonization induces dynamic temporal and spatial patterns of NF-κB activation in the zebrafish digestive tract

作者: Michelle Kanther , Xiaolun Sun , Marcus Mühlbauer , Lantz C. Mackey , Edward J. Flynn

DOI: 10.1053/J.GASTRO.2011.03.042

关键词: Cell biologyZebrafishEnhancerMolecular biologyRegulation of gene expressionToll-like receptorTissue homeostasisTranscription factorGene expressionTranscriptional regulationBiology

摘要: … indicate that cells in the gastrointestinal tract respond robustly to the microbial environment. … zebrafish cells to bacterial cell lysate. The Gram-negative γ-proteobacterium Pseudomonas …

参考文章(55)
J. F. Rawls, B. S. Samuel, J. I. Gordon, Gnotobiotic zebrafish reveal evolutionarily conserved responses to the gut microbiota. Proceedings of the National Academy of Sciences of the United States of America. ,vol. 101, pp. 4596- 4601 ,(2004) , 10.1073/PNAS.0400706101
María P. Sepulcre, Francisca Alcaraz-Pérez, Azucena López-Muñoz, Francisco J. Roca, José Meseguer, María L. Cayuela, Victoriano Mulero, Evolution of Lipopolysaccharide (LPS) Recognition and Signaling : Fish TLR4 Does Not Recognize LPS and Negatively Regulates NF-κB Activation Journal of Immunology. ,vol. 182, pp. 1836- 1845 ,(2009) , 10.4049/JIMMUNOL.0801755
Sankar Ghosh, Matthew S. Hayden, New regulators of NF-kappaB in inflammation. Nature Reviews Immunology. ,vol. 8, pp. 837- 848 ,(2008) , 10.1038/NRI2423
Harald Carlsen, Jan Ø. Moskaug, Sigurd H. Fromm, Rune Blomhoff, In Vivo Imaging of NF-κB Activity Journal of Immunology. ,vol. 168, pp. 1441- 1446 ,(2002) , 10.4049/JIMMUNOL.168.3.1441
Kris A. Steinbrecher, Eleana Harmel-Laws, Raquel Sitcheran, Albert S. Baldwin, Loss of epithelial RelA results in deregulated intestinal proliferative/apoptotic homeostasis and susceptibility to inflammation. Journal of Immunology. ,vol. 180, pp. 2588- 2599 ,(2008) , 10.4049/JIMMUNOL.180.4.2588
Asha L. Bhakar, Laura-Lee Tannis, Christine Zeindler, Maria Pia Russo, Christian Jobin, David S. Park, Sandra MacPherson, Philip A. Barker, Constitutive Nuclear Factor-κB Activity Is Required for Central Neuron Survival The Journal of Neuroscience. ,vol. 22, pp. 8466- 8475 ,(2002) , 10.1523/JNEUROSCI.22-19-08466.2002
Scott T. Magness, Humberto Jijon, Nancy Van Houten Fisher, Ned E. Sharpless, David A. Brenner, Christian Jobin, In Vivo Pattern of Lipopolysaccharide and Anti-CD3-Induced NF-κB Activation Using a Novel Gene-Targeted Enhanced GFP Reporter Gene Mouse Journal of Immunology. ,vol. 173, pp. 1561- 1570 ,(2004) , 10.4049/JIMMUNOL.173.3.1561
Con Sullivan, Jeremy Charette, Julian Catchen, Christopher R. Lage, Gregory Giasson, John H. Postlethwait, Paul J. Millard, Carol H. Kim, The Gene History of Zebrafish tlr4a and tlr4b Is Predictive of Their Divergent Functions Journal of Immunology. ,vol. 183, pp. 5896- 5908 ,(2009) , 10.4049/JIMMUNOL.0803285
Caryn Y. Ito, Alexey G. Kazantsev, Albert S. Baldwin, Three NF-χB sites in the IχB-α promoter are required for induction of gene expression by TNFα Nucleic Acids Research. ,vol. 22, pp. 3787- 3792 ,(1994) , 10.1093/NAR/22.18.3787
Masanori Tobe, Yoshiaki Isobe, Hideyuki Tomizawa, Takahiro Nagasaki, Hirotada Takahashi, Tominaga Fukazawa, Hideya Hayashi, Discovery of quinazolines as a novel structural class of potent inhibitors of NF-κB activation Bioorganic & Medicinal Chemistry. ,vol. 11, pp. 383- 391 ,(2003) , 10.1016/S0968-0896(02)00440-6