Urinary LDH-release for evaluation of postischemic renal function

摘要: Following renal ischemia under protection, the perfusion of tubular system increases concomitant to rise GFR. The transport into urine enzymes entering lumen due ischemic injury is dependent on flow. Thus, we examined if in early post-ischemic phase urinary enzyme determinations can contribute evaluation a changing washout. Canine kidneys were perfused with different protective solutions and subsequently rendered ischemic. From beginning reperfusion endogenous creatinine clearance, minute volume LDH-concentration determined. allowed only rough assessment damage. adjustment LDH amounts GFR resulted better graduation according stress. With such standardized parameter release was somewhat lower average when L-aspartate added HTK solution place chloride. In conclusion, during postischemic recovery after protection examination may be useful diagnostic means for extent an appropriate frame reference applied.