Effect of nonspecific forces and finite receptor number on rate constants of ligand--cell bound-receptor interactions

摘要: Abstract We develop a theory of ligand diffusion in the presence central potential toward or away from receptor patches that are uniformly distributed over spherical cell. The current onto receptors is reduced to less than sphere by factor nonlinear function number free receptors, their size, and energy. Similarly, under conditions defined theory, dissociation rate probability rebinding some other on same This complicates kinetic analysis, leading possibility an occupancy-dependent rate, but has no effect interpretation thermodynamic data.