High-throughput evaluation of lipophilicity and acidity by new gradient HPLC methods.
作者： Michal Markuszewski , Pawel Wiczling , Roman Kaliszan
关键词: Analytical chemistry 、 High-performance liquid chromatography 、 Ph gradient 、 Chromatography 、 Chemistry 、 Partition coefficient 、 Titration 、 Phase (matter) 、 Large series 、 Analyte 、 Lipophilicity
摘要: … as a measure of drug lipophilicity. Routinely, log kw is obtained in a series of isocratic HPLC experiments. The general methodology of determination of lipophilicity by reversedphase …
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