A sequence-dependent combination of docetaxel and vinorelbine: pharmacokinetic interactions
作者： Luigi Cattel , Valeria Recalenda , Mario Airoldi , Valentina Tagini , Silvia Arpicco
DOI: 10.1016/S0014-827X(01)01138-7
关键词: Pharmacology 、 Vinblastine 、 Endocrinology 、 Vinorelbine 、 Internal medicine 、 Chemistry 、 Bolus (medicine) 、 Cmax 、 Paclitaxel 、 Toxicity 、 Pharmacokinetics 、 Docetaxel
摘要: We studied possible pharmacokinetic interactions between docetaxel (DTX) and vinorelbine (VNR) in patients affected by different types of cancer. Patients with metastatic breast cancer or recurrent head neck received the following schedules: Protocol A: 11 were i.v. infused for 1 h DTX (80 mg/m2) at once, followed VNR (25 as slow bolus; B: a 10 min bolus was administered to 12 patients, immediately infusion mg/m2). In both schedules, plasma concentrations versus time analysed HPLC obtaining corresponding non-compartmental parameters. appeared pharmacokinetically sequential administration DTX, since protocol B, Cmax AUC significantly higher clearance lower than A. Moreover, significant increase level observed correspondence peak DTX. By contrast, Cmax, did not vary two protocols. Also number neutrophils nadir on day 8 treatment varied schedules. conclusion we altered parameters A (DTX, VNR) B (VNR/DTX). particular, seemed be exposed concentration haematological toxicity.
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