Evaluation of the Quality of Life Associated with Zidovudine Treatment in Asymptomatic Human Immunodeficiency Virus Infection
作者： William R. Lenderking , Richard D. Gelber , Deborah J. Cotton , Bernard F. Cole , Aron Goldhirsch
DOI: 10.1056/NEJM199403173301102
关键词: Acquired immunodeficiency syndrome (AIDS) 、 Medicine 、 Clinical trial 、 Zidovudine 、 Randomized controlled trial 、 Placebo 、 Quality of life 、 Asymptomatic 、 Surgery 、 Internal medicine 、 Adverse effect
摘要: Background Zidovudine therapy is recommended for asymptomatic patients infected with the human immunodeficiency virus (HIV) who have fewer than 500 CD4+ cells per cubic millimeter. An analysis of quality life associated that integrated both effects adverse events and benefits delayed disease progression might influence this recommendation. Methods We applied a survival adjusted to data from randomized trial conducted by AIDS Clinical Trials Group. The compared treatment mg zidovudine day, 1500 placebo (Protocol 019) in 1338 HIV-infected patients. Results average time neither nor an event (symptom or laboratory finding) was 15.7, 15.6, 14.8 months receiving placebo, zidovudine, respectively. incidence severe symptoms 13.8 percent group, 15.2 i...
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