Disease-Related, Nondisease-Related, and Situational Catastrophizing in Sickle Cell Disease and Its Relationship With Pain.

摘要: Abstract Catastrophizing is a potent psychological modulator of pain across several chronic populations; yet despite evidence that patients with sickle cell disease (SCD) catastrophize more than other conditions, previous research indicates catastrophizing not related to after controlling for relevant covariates such as depression. Recent suggests pain-related should be assessed contexts (eg, dispositional and situational). In this study, we measured disease-specific, general non-disease-related, situational the relationship between these contextual dimensions laboratory clinical among SCD. Results revealed differential contexts, reporting greater about SCD-specific compared non-SCD pain. were associated outcomes, markers central sensitization Further examination time course responses increases in subsequent sensitivity. Taken together, results show relevance understanding SCD, suggest context-specific anchors may beneficial predicting different aspects experience pain, sensitization). Perspective Patients SCD report cell-specific relative pains. Disease-specific non-disease-related predictive Evaluation accurately predict experience.