Comparative phylogenetic analysis of SARS-CoV-2 spike protein-possibility effect on virus spillover.

摘要: Coronavirus disease 2019 has developed into a dramatic pandemic with tremendous global impact. The receptor-binding motif (RBM) region of the causative virus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), binds to host angiotensin-converting enzyme (ACE2) receptors for infection. As ACE2 are highly conserved within vertebrate species, SARS-CoV-2 can infect significant animal species as well human populations. An analysis genotypes isolated from and was conducted compare identify mutation adaptation patterns across different species. phylogenetic data revealed seven distinct clades no relationship between geographical locations. A high rate variation mink isolates implies that populations were infected before Positions most single-nucleotide polymorphisms (SNPs) spike (S) protein hosts mostly accumulated in RBM highlight pronounced accumulation variants mutations comparison other variants. These SNPs play crucial role viral transmission pathogenicity keys identifying potential intermediate SARS-CoV-2. possible roles emergence new strains implications these changes, compromising vaccine effectiveness, deserve urgent considerations.