Magnesium Sulfate for the Treatment of Eclampsia: A Brief Review
作者： Anna G. Euser , Marilyn J. Cipolla
DOI: 10.1161/STROKEAHA.108.527788
关键词: Eclampsia 、 Vasoconstriction 、 Epilepsy 、 Anticonvulsant 、 Blood–brain barrier 、 Medicine 、 Internal medicine 、 Magnesium 、 Vasodilation 、 Vascular resistance 、 Endocrinology
摘要: Background and Purpose— Magnesium sulfate is used extensively for prevention of eclamptic seizures. Empirical clinical evidence supports the effectiveness magnesium sulfate; however, questions remain as to its safety mechanism. This review summarizes current supporting possible mechanisms action several controversies treatment. Summary Review— Several are presented, including effects on peripheral cerebral vasodilation, blood-brain barrier protection, an anticonvulsant. Conclusions— Though specific unclear, effect in eclampsia likely multi-factorial. may act a vasodilator, with actions vasculature or cerebrovasculature, decrease vascular resistance relieve vasoconstriction. Additionally, also protect limit edem...
sci-hub.se 参考文章(100)
Monica Longo, Venu Jain, Yuri P. Vedernikov, Fabio Facchinetti, George R. Saade, Robert E. Garfield, Endothelium dependence and gestational regulation of inhibition of vascular tone by magnesium sulfate in rat aorta. American Journal of Obstetrics and Gynecology. ,vol. 184, pp. 971- 978 ,(2001) , 10.1067/MOB.2001.112587
James Donaldson, Eclamptic hypertensive encephalopathy. Seminars in Neurology. ,vol. 8, pp. 230- 233 ,(1988) , 10.1055/S-2008-1041383
Jack A. Pritchard, F.Gary Cunningham, Signe A. Pritchard, The Parkland Memorial Hospital protocol for treatment of eclampsia: evaluation of 245 cases. American Journal of Obstetrics and Gynecology. ,vol. 148, pp. 951- 963 ,(1984) , 10.1016/0002-9378(84)90538-6
C P Aloamaka, M Ezimokhai, J Morrison, T Cherian, Effect of pregnancy on relaxation of rat aorta to magnesium Cardiovascular Research. ,vol. 27, pp. 1629- 1633 ,(1993) , 10.1093/CVR/27.9.1629
John W. Goldkrand, Armando M. Fuentes, The relation of angiotensin-converting enzyme to the pregnancy-induced hypertension-preeclampsia syndrome. American Journal of Obstetrics and Gynecology. ,vol. 154, pp. 792- 800 ,(1986) , 10.1016/0002-9378(86)90460-6
Sharon H. Nelson, Maya S. Suresh, Magnesium sulfate-induced relaxation of uterine arteries from pregnant and nonpregnant patients* American Journal of Obstetrics and Gynecology. ,vol. 164, pp. 1344- 1350 ,(1991) , 10.1016/0002-9378(91)90711-Y
Lawrence F. Borges, Giindilz Giicer, Effect of magnesium on epileptic foci. Epilepsia. ,vol. 19, pp. 81- 91 ,(2007) , 10.1111/J.1528-1157.1978.TB05015.X
R Dingledine, M A Hynes, G L King, Involvement of N-methyl-D-aspartate receptors in epileptiform bursting in the rat hippocampal slice. The Journal of Physiology. ,vol. 380, pp. 175- 189 ,(1986) , 10.1113/JPHYSIOL.1986.SP016279
Zeev Feldman, Boris Gurevitch, Alan A. Artru, Arieh Oppenheim, Esther Shohami, Eli Reichenthal, Yoram Shapira, Effect of magnesium given 1 hour after head trauma on brain edema and neurological outcome. Journal of Neurosurgery. ,vol. 85, pp. 131- 137 ,(1996) , 10.3171/JNS.1996.85.1.0131
Allison M. Quick, J. Marilyn Cipolla, Pregnancy-induced up-regulation of aquaporin-4 protein in brain and its role in eclampsia The FASEB Journal. ,vol. 19, pp. 170- 175 ,(2005) , 10.1096/FJ.04-1901HYP