Vessel for growth of biological entities
作者： Kladias Nikolaos Pantelis , Wall Joseph Christopher , Rammohan Aravind Raghavan , Youngbear Kathy Marie , Kenney David Alan
DOI:
关键词: Biomedical engineering 、 Biological media 、 Structural engineering 、 Volume (thermodynamics) 、 Aeration 、 Bioreactor 、 Shear stress 、 Baffle 、 Materials science
摘要: A 5-liter bioreactor vessel enables a substantial increase in the volume of biological media that can be cultivated compared to conventional designs. Moreover, when agitated at 1.5× shaking frequency 3-liter (i.e., 90 rpm versus 60 rpm), achieves 19% cell aeration without exceeding maximum shear stress limit for viability. The optionally includes plurality internal baffles configured disrupt liquid vortex and reduce transferred biomedia contained within vessel.
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