Enantioselective organocatalytic conjugate addition of α-nitroacetate to α,β-unsaturated ketones in water
作者： Hyoung Wook Moon , Dae Young Kim
DOI: 10.1016/J.TETLET.2010.03.105
关键词: Catalysis 、 Reaction conditions 、 Adduct 、 Organic chemistry 、 Chemistry 、 Bifunctional 、 Conjugate 、 Addition reaction 、 Enantioselective synthesis 、 Michael reaction
摘要: Abstract The catalytic enantioselective conjugate addition reaction of α-nitroacetate to α,β-unsaturated ketones promoted by chiral bifunctional organocatalysts is described. treatment under aqueous-phase conditions afforded the corresponding Michael adducts with high enantioselectivity. are easily converted δ-keto nitroalkanes and esters.
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