Selective Aspiration or Neurotoxic Lesions of Orbital Frontal Areas 11 and 13 Spared Monkeys' Performance on the Object Discrimination Reversal Task

摘要: Damage to the orbital frontal cortex (OFC) has long been associated with reversal learning deficits in several species. In monkeys, this impairment follows lesions that include OFC subfields. However, different connectional patterns of subfields together neuroimaging data humans have suggested specific areas play distinctive roles processing information necessary guide behavior (Kringelbach and Rolls, 2004; Barbas, 2007; Price, 2007). More specifically, 11 13 contribute a sensory network, whereas medial 10, 14, 25 are heavily connected visceromotor network. To examine contribution learning, we tested monkeys selective damage these two on versions ODR task using either one or five discrimination problems. We compared their performance sham-operated controls animals neurotoxic amygdala lesions, which served as operated controls. Neither nor affected tasks. The results indicate do not critically adjacent (10, 12, 25) could account for found earlier lesion studies. This sparing will be discussed relation same tasks measure behavioral modulation when relative value affective (positive negative) stimuli was manipulated.