Size of Neurotransmitter Receptors as Determined by Radiation Inactivation–Target Size Analysis

摘要: Publisher Summary The principal receptors of the autonomic nervous system are adrenergic and cholinergic receptors. Adrenergic responses have been most extensively studied because their overall physiological importance. β-Adrenergic receptors, which modulate a diverse array cellular organ functions including heart rate vascular airway diameter, received extensive attention demonstrated role in activation adenylate cyclase activity. Nicotinic acetylcholine control skeletal muscle contraction certain aspects ganglionic function, consequently receptor about is known. genes for nicotinic cloned complete amino acid sequence has determined. purification structural elucidation aided tremendously, particularly early stages, by having rich source (electric eels) specific probes (cobra toxins). resolution structure (α β), muscarinic cholinergic, dopaminergic clearly underway variety laboratories throughout world. Structural determinations generally depended on application new technologies development affinity ligands. chapter discusses target size analysis, reemerging technique, obtaining information number