History of Endothelin

摘要: It had long been considered that noradrenaline released from autonomic sympathetic nerves and classical humoral factors, including renin-angiotensin, vasopressin adrenaline, regulate vascular tonus by directly contracting smooth muscle. In other words, peripheral resistance is maintained mostly vasocontraction produced these vasorelaxation passively induced when their influence diminishes. Within the past two decades, however, existence of definite active mechanisms has uncovered, e.g., peptidergic [1] nitric oxidergic [2] nerves, vasorelaxing substances atrial natriuretic peptides (ANP) [3], adrenomedullin [4], endothelium-derived relaxing factors (EDRF) [5]. Vascular endothelium consists only one layer endothelial cells on inner surface blood vessel plays an important role as a barrier against contacting muscle cells, hence preventing coagulation. addition to this influence, have revealed producing releasing potent vasoactive substances, (EDCF), well EDRF. A number exert not short-term or actions but also long-term hypertrophic hyperplastic cardiovascular tissues. Thus, structure function appear be controlled large endogenous in complicated manner.