作者: Marina Di Domenico , Federica Pinto , Lucio Quagliuolo , Maria Contaldo , Giuliana Settembre
关键词: Bioinformatics 、 Obesity 、 Hormone 、 Lifestyle factors 、 Adipose tissue 、 Epigenetics 、 Oxidative stress 、 Caloric intake 、 Morbid obesity 、 Medicine
摘要: The accumulation of adipose tissue in the body occurs because energy introduced with food and drink exceeds that expense, but to understand why this imbalance is established it maintained over time, important consider main causes risk factors excess weight. In review, we will refer linked obesity, starting from oxidative stress hormonal including role obesity breast cancer. Among many hypotheses formulated on etiopathology a key can be attributed relationship between intestinal microbiota. Multiple evidences tend show genetic, epigenetic, lifestyle contribute determine obese an redox balance correlated alteration microbial flora. Obesity acts negatively wound healing, fact several studies indicate morbid significantly increased post-operative complication infection. Currently, treatment medical interventions are aimed not only at modifying caloric intake, also modulate improve composition diet aim rebalancing microbiota-redox state axis.