Management of bone metastases in cancer: A review

作者: Giovanni Selvaggi , Giorgio V. Scagliotti

DOI: 10.1016/J.CRITREVONC.2005.03.011

关键词: MedicineBone metastasisPathologic fractureOncologyBone Density Conservation AgentsDisseminated diseaseCancerInternal medicineClinical trialBasic researchRadiation therapySurgery

摘要: The presence of bone metastases is indicative disseminated disease and typically indicates a short-term prognosis in cancer patients. Palliation symptoms the primary goal therapy, with multidisciplinary efforts yielding best results. New classes drugs, such as bisphosphonates that significantly increase time to first skeletal-related event (SRE), represent useful tools for treatment metastases. While optimal duration therapy needs be defined, there clinical benefit derived from use this class agents. A potential role prevention under current evaluation trials encompassing different solid tumor types. In combination ongoing trials, basic research identify novel targets cells-bone microenvironment will further define future strategies

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