Thyroid autoantibodies per se do not impair intracytoplasmic sperm injection outcome in euthyroid healthy women

摘要: Objective: Autoimmune thyroid disease (AITD) has been associated with adverse pregnancy outcomes in subfertile women spontaneous and assisted reproductive technology-induced pregnancies. The underlying pathophysiology is still elusive an association dysfunction or other infertility causes discussed. However, whether autoimmunity (TAI) per se a negative impact on female fertility not yet clarified. In this study, we investigated TAI healthy undergoing intracytoplasmic sperm injection (ICSI) for male may affect outcome. Design: A retrospective, single-centre study. Methods: ICSI outcome data obtained from 835 euthyroid (age: 31.4G4.3 years, BMI: 23.7G4.2 kg/m 2 ) were correlated pre-ICSI status. known of subfertility excluded. Outcome parameters included rates pregnancy, birth, miscarriage preterm delivery. Blood analysis was carried out retrospectively using blood samples drawn before ICSI. defined by elevation anti-thyroperoxidase- anti-thyroglobulin-antibodies O100 U/l. Results: TAI-positive -negative groups did differ age, BMI TSH levels. status influence any parameters. contrast, increasing maternal age significantly lower rate (odds ratio (OR): 0.94 (95% CI: 0.91‐0.97); PZ0.0003) birth (OR: 0.93 0.09‐0.97); P!0.0001). Conclusions: Our study suggests that does strict definition AITD consideration TAI-associated -independent confounders are important to further elucidate the interplay between reproduction.