First-pass metabolism of imipramine in man.
作者： Lars F. Gram , Johannes Christiansen
关键词: Excretion 、 Demethylation 、 Metabolism 、 Oral administration 、 Metabolite 、 Imipramine 、 Urine 、 Pharmacology 、 Endocrinology 、 First pass effect 、 Internal medicine 、 Chemistry
摘要: The systemic availability of orally administered imipramine (IP) varied from 29 to 77% in 4 subjects. decrease was due an excess metabolism after oral administration. This first%pass did not correlate with plasma half%life, apparent clearance, or the rate metabolite excretion urine. There close correlation formation demethylated metabolites administration, which suggests that is mediated by demethylation, but does total demethylation.
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