Polyacylurethanes as Novel Degradable Cell Carrier Materials for Tissue Engineering

摘要: Polycaprolactone (PCL) polyester and segmented aliphatic urethanes based on PCL soft segment have been thoroughly investigated as biodegradable scaffolds for tissue engineering. Although proven beneficial long term implants, these materials degrade very slowly are therefore not suitable in applications which scaffold support is needed a shorter time. A recently developed class of polyacylurethanes (PAUs) expected to fulfill such requirements. Our aim was assess vitro the degradation PAUs evaluate their suitability temporary repair. With both mass loss 2.5–3.0% decrease molar approx. 35% over period 80 days, were shown via bulk surface erosion mechanisms. Fourier Transform Infra Red (FTIR) spectroscopy successfully applied study extent microphase separation during degradation. The separated morphology PAU1000 (molar oligocaprolactone = 1000 g/mol) provided this polymer with mechano-physical characteristics that would render it material constructs devices. exhibited excellent haemocompatibility vitro. In addition, supported adhesion proliferation vascular endothelial cells could be further enhanced by pre-coating fibronectin (Fn). contact angle decreased incubation biological fluids. cell culture medium reached 60°, optimal adhesion. Taken together, results application field repair degradable scaffold.