Mitral valve prolapse and mitral regurgitation are common in patients with polycystic kidney disease type 1
作者： Anne Lumiaho , Risto Ikäheimo , Raija Miettinen , Lea Niemitukia , Tomi Laitinen
关键词: Mitral regurgitation 、 Mitral valve prolapse 、 Autosomal dominant polycystic kidney disease 、 Polycystic kidney disease 、 Internal medicine 、 Kidney disease 、 Medicine 、 Left ventricular hypertrophy 、 Mitral valve 、 Blood pressure 、 Cardiology
摘要: Patients with autosomal dominant polycystic kidney disease (ADPKD) have an increased occurrence of cardiac valve abnormalities. However, the prevalence abnormalities in patients a uniform genotype ADPKD has not been previously reported. We performed M-mode and color Doppler echocardiography on 109 from 16 families type 1 (PKD1). Findings were compared those 73 unaffected family members healthy controls. Mitral prolapse was found 26% PKD1, 14% relatives, 10% control subjects. The hemodynamically significant mitral regurgitation (grade 2 or 3) 13%, 4%, 3%, respectively. Prevalences grade 3 aortic (8%, respectively) tricuspid (4%, 6%, 7%, significantly different among three groups. Left ventricular hypertrophy (LVH) 19% subjects 6% 4% Systolic blood pressure severity renal insufficiency related to LVH PKD1. did differ between relatives is characteristic finding Conversely, are likely be secondary elevated these patients.
ajkd.org
elsevier.com参考文章(44)
Gabor Gyapay, Jean Morissette, Alain Vignal, Colette Dib, Cécile Fizames, Philippe Millasseau, Sophie Marc, Giorgio Bernardi, Mark Lathrop, Jean Weissenbach, The 1993-94 Généthon human genetic linkage map. Nature Genetics. ,vol. 7, pp. 246- 339 ,(1994) , 10.1038/NG0694SUPP-246
V Parsons, E S Garnett, C Chantler, N Veall, Glomerular filtration rate measurement in man by the single injection methods using 51Cr-EDTA. Clinical Science. ,vol. 37, pp. 169- 180 ,(1969)
B. Peral, R. L. Stallings, R. L. Stallings, S. Thomas, J. L. San Millán, P. C. Harris, F. Moreno, C. J. Ward, Evidence of linkage disequilibrium in the Spanish polycystic kidney disease I population. American Journal of Human Genetics. ,vol. 54, pp. 899- 908 ,(1994)
I. A. D'Cruz, G. G. Lalmalani, V. Sambasivan, H. C. Cohen, G. Glick, The superiority of mitral E point-ventricular septum separation to other echocardiographic indicators of left ventricular performance. Clinical Cardiology. ,vol. 2, pp. 140- 145 ,(1979) , 10.1002/CLC.4960020210
P Gabow, R W Schrier, A M Johnson, S Rainguet, A B Chapman, K Hossack, Left ventricular hypertrophy in autosomal dominant polycystic kidney disease. Journal of The American Society of Nephrology. ,vol. 8, pp. 1292- 1297 ,(1997) , 10.1681/ASN.V881292
Alan F. Wright, Peter W. Teague, Susan E. Pound, Patricia M. Pignatelli, Anne M. Macnicol, Andrew D. Carothers, Rhona J. De Mey, Paul L. Allan, Michael L. Watson, A study of genetic linkage heterogeneity in 35 adult-onset polycystic kidney disease families. Human Genetics. ,vol. 90, pp. 569- 571 ,(1993) , 10.1007/BF00217461
Janine Krivokapich, John S. Child, Berge J. Dadourian, Joseph K. Perloff, Reassessment of echocardiographic criteria for diagnosis of mitral valve prolapse. American Journal of Cardiology. ,vol. 61, pp. 131- 135 ,(1988) , 10.1016/0002-9149(88)91318-5
A Bardaji, AM Vea, C Gutierrez, C Ridao, C Richart, JA Oliver, Left ventricular mass and diastolic function in normotensive young adults with autosomal dominant polycystic kidney disease American Journal of Kidney Diseases. ,vol. 32, pp. 970- 975 ,(1998) , 10.1016/S0272-6386(98)70071-X
D. Ravine, Lj Sheffield, D.M. Danks, R.N. Gibson, R.G. Walker, P. Kincaid-Smith, Evaluation of ultrasonographic diagnostic criteria for autosomal dominant polycystic kidney disease 1. The Lancet. ,vol. 343, pp. 824- 827 ,(1994) , 10.1016/S0140-6736(94)92026-5
Göran Granerus, Mattias Aurell, Reference values for 51Cr-EDTA clearance as a measure of glomerular filtration rate. Scandinavian Journal of Clinical & Laboratory Investigation. ,vol. 41, pp. 611- 616 ,(1981) , 10.3109/00365518109090505