Predictive models for nanotoxicology: in vitro, in vivo, and computational models

摘要: Abstract Nanotechnologies are becoming widely applied in various industries, leading to increasing health and environmental concern due possible nanomaterial exposure. Development of predictive models for nanotoxicology is important evaluate hazard risk potentially caused by engineered nanomaterials. Toxicological data from reliable therefore crucial order design safe effective nanomaterials world-wide applications. In this chapter, the development application including vitro, vivo computational nanotoxicological studies summarized highlighted. The chapter covers definition nanotoxicology, discusses vitro ranging conventional 2D cell-based model 3D-tissue model, organ-on-a-chip, considers animal focusing on rodent-type alternative models, reviews their studies.